Zylkene
Natural calming supplement derived from a milk protein. Not a POM-V medicine - available without prescription. Used for mild stress, travel, kennelling and adjustment periods. Active ingredient: alpha-casozepine.
See your saving over a year
Pick your dog's weight (and optionally your vet's actual quote) to see the exact monthly and annual saving. The price comparison table below sorts pharmacies by cheapest first; we never sort by commission.
Based on a 15 kg dog, recommended strength: 225 mg. Assumes 12 months of continuous use (chronic dosing) and one written prescription per year. CMA Order caps the prescription fee at £21 for the first medicine, plus £12.50 per additional medicine on the same prescription. Prices are indicative and last verified 2026-05-15. Always confirm the current price on the pharmacy site before purchase.
Why it costs more at the vet
Vionate / Vetoquinol product, often sold in clinic at full RRP. Because it is not POM-V you do not need a prescription, but it is still cheaper online.
Common side effects
- None significant
Not a complete list. Always read the patient information leaflet and speak to your vet about side effects.
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Copy-paste email template, prescription steps and refill setup. From "I just paid too much at the vet" to "I'm saving £X every month".
How to get a written prescription
The CMA Order is legally binding by 23 September 2026. Every UK vet must offer a written prescription on request, with the fee capped at £21 for the first medicine plus £12.5 per additional medicine on the same prescription. Take the prescription to any VMD-approved online pharmacy listed above.
Common questions
- Do I need a prescription for Zylkene?
- No - it is a nutraceutical, not POM-V. You can order it directly from any pharmacy or pet retailer.
- How long before an event should I start Zylkene?
- Start at least 1-2 days before, ideally a week. It is not a same-day calmer like Sileo.
Similar medications
Track Zylkene price drops
We'll email when Zylkene drops in price at any of the pharmacies above.
Stop overpaying for Zylkene.
Same medicine, same regulator, same vet relationship — half the price. Five-minute switch from in-clinic dispensing to a VMD-approved online pharmacy.
Pricing data status: indicative. Last verified 2026-05-15. Pharmacies change prices regularly — always confirm before purchase. Not medical advice.